Management of Dementia from the Preclinical Stage

This book introduces dementia and its related disorder featured with the updated information from basic sciences such as newly found biomarkers to clinical treatments. The treatments contain the pharmacological including updated clinical trials and non-pharmacological interventions from traditional multiple modalities intervention to digital medicines including basic concept of artificial intelligence (AI) with its clinical application. It updates the clinical phenotypes of successful aging to dementia along with accompanied biomarkers in various stages to help readers how to recognize these stages scientifically. Meanwhile, authors updates the risks factors with their managements such as cardiovascular risks, atrial fibrillation, diabetic mellitus, hypertension, or metabolic syndrome etc., or other manipulable risks. AI application is increasing recently. Authors introduce basic concepting of how AI working and computing to assist professional physicians or researchers in clinical managements or basic researches. Authors provide and update the innovative managements of non-invasive interventions for dementia such as gamma oscillation or other physical intervention with their clinical applications. The new concepts of epileptic discharge, brain electrical activity to dementia, are also reported and summarized in the book to have a new vision of degenerative process of cerebral aging.