Clinical Atlas of Genodermatoses in Skin of Colour

Genodermatoses are a diverse group of inherited disorders caused by genetic mutations, often involving the skin, mucosa, and adnexal structures. As the most accessible and visible organ, the skin frequently offers vital diagnostic clues—such as café-au-lait macules in neurofibromatosis, angiofibromas in tuberous sclerosis, or ichthyosis linearis circumflexa in Netherton syndrome, that may be overlooked by the untrained eye. Early recognition of these hallmark lesions can lead to prompt diagnosis and timely management.

With the advent of advanced genetic testing and expanding access to molecular diagnostics, the identification of genodermatoses is steadily increasing. In parallel, developments in proteomics and targeted therapies are offering promising therapeutic avenues. Against this background, clinical suspicion and early recognition remain crucial.

Most existing textbooks on genodermatoses are authored in Western contexts, and the accompanying clinical images often do not represent how these conditions appear in skin of colour. This atlas aims to bridge that gap by presenting high-quality clinical images of genodermatoses as seen in skin of colour, accompanied by concise, structured discussions tailored for practical use.