Biomarkers and Therapeutical Targets for Prion Diseases
Springer
ISBN 978-3-031-97054-2
Standardpreis
Bibliografische Daten
Fachbuch
Buch. Hardcover
2025
48 s/w-Abbildungen, 16 Farbabbildungen.
In englischer Sprache
Umfang: vi, 320 S.
Format (B x L): 15,5 x 23,5 cm
Verlag: Springer
ISBN: 978-3-031-97054-2
Weiterführende bibliografische Daten
Das Werk ist Teil der Reihe: Subcellular Biochemistry
Produktbeschreibung
The rational development of theranostic small molecules for prion diseases is also included, shedding light on potential treatment. It examines the utility of prion disease diagnostic markers in pre-symptomatic disease stages, offering insights into early detection strategies.
Pharmacological approaches in prion diseases are explored, along with the potential of Lab-on-Chip platforms for monitoring prion and "prion-like" amyloid assembly and behavior. The role of reactive microglia and astrocytes as therapeutic targets is investigated, highlighting novel avenues for intervention.
Furthermore, the book addresses biological fluid biomarkers in human prion diseases, paying special attention to biosafety considerations. Human genetic evidence is analyzed to identify new targets in prion diseases, discussing both opportunities and challenges.
The utilization of RT-QuIC analysis of peripheral tissues and PMCA applications in prion disease diagnosis is examined, along with the extension of seed amplification assays for the clinical diagnosis of neurodegenerative disorders beyond prion pathologies. Overall, the book provides a comprehensive overview of biomarkers and therapeutic targets in prion diseases, encapsulating both current knowledge and emerging trends in the field.
Chapter 10 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
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