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Kumar

Fused Pyrimidine-Based Drug Discovery

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ca. 214.00 €

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Buch. Softcover

2022

320 S.

In englischer Sprache

William Andrew Publishing. ISBN 978-0-12-824531-6

Format (B x L): 15,2 x 22,9 cm

Das Werk ist Teil der Reihe: Heterocyclic Drug Discovery

Produktbeschreibung

Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents, and many more.

This book focuses on nomenclature, structural chemistry, and chemical and physical properties, along with various approaches for their synthesis. It is ideal for researchers in organic chemistry, both in academic and industrial settings and for postgraduates in chemistry and medicinal chemistry.


- Features synthetic schemes, approaches and strategies for fused pyrimidine scaffolds
- Includes new fused-pyrimidine scaffolds, allowing the researcher to predict the mechanisms involved in their synthesis
- Covers in silico studies of known fused pyrimidines and Structure Activity Relationship (SAR) that encourage the development of new or modified existing scaffolds with specific biological activities

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