Yan / Caldwell

Cytochrome P450

In Vitro Methods and Protocols

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

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128,39 €

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Fachbuch

Buch. Softcover

2022

xi, 379 S. 54 s/w-Abbildungen, 40 Farbabbildungen, Bibliographien.

In englischer Sprache

Humana. ISBN 978-1-07-161544-7

Format (B x L): 17,8 x 25,4 cm

Gewicht: 743 g

Das Werk ist Teil der Reihe: Methods in Pharmacology and Toxicology

Produktbeschreibung

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading.
Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.