Erschienen: 03.02.2011 Abbildung von Vogel / Maas / Gebauer | Drug Discovery and Evaluation: Methods in Clinical Pharmacology | 2011

Vogel / Maas / Gebauer

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

lieferbar, ca. 10 Tage

699,97 €

inkl. Mwst.

2011. Buch. xii, 564 S. 138 s/w-Abbildungen, Bibliographien

Springer. ISBN 978-3-540-89892-4

Format (B x L): 19,3 x 26 cm

In englischer Sprache

Produktbeschreibung

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined.

As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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