Erschienen: 07.03.2012 Abbildung von Thomas-Tikhonenko | Cancer Genome and Tumor Microenvironment | 2012

Thomas-Tikhonenko

Cancer Genome and Tumor Microenvironment

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

ca. 279,99 €

inkl. Mwst.

2012. Buch. ix, 480 S. 29 s/w-Abbildungen, 16 Farbabbildungen, 9 s/w-Tabelle, Bibliographien. Softcover

Springer. ISBN 978-1-4614-2524-3

Format (B x L): 15,5 x 23,5 cm

Gewicht: 777 g

In englischer Sprache

Das Werk ist Teil der Reihe: Cancer Genetics

Produktbeschreibung

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

Autoren

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