Erschienen: 28.03.2019 Abbildung von Scott / Laporte | Beta-Arrestins | 1. Auflage | 2019 | 1957 |

Scott / Laporte


Methods and Protocols

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192,59 €

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Buch. Hardcover

1st ed. 2019. 2019

xiv, 409 S. 19 s/w-Abbildungen, 60 Farbabbildungen, 58 Farbtabellen, Bibliographien.

In englischer Sprache

Humana. ISBN 978-1-4939-9157-0

Format (B x L): 17,8 x 25,4 cm

Gewicht: 1013 g

Das Werk ist Teil der Reihe: Methods in Molecular Biology; 1957


This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson’s disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins.

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