Erschienen: 29.06.2015 Abbildung von Schmitz | An investigation of microRNA target regulation mechanisms using an integrative approach | 2015

Schmitz

An investigation of microRNA target regulation mechanisms using an integrative approach

lieferbar, ca. 10 Tage

2015. Buch. 192 S. Softcover

Logos. ISBN 978-3-8325-4005-0

Format (B x L): 14,5 x 21 cm

In englischer Sprache

Produktbeschreibung

This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

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