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Presents an essential question that needs to be answered in order to estimate the burden of disease in any population: What is the size of a hard-to-reach / unobserved populations at risk for a disease? Provides an overview of the different methods to estimate the size of hard-to-reach populations, with an extensive focus on the network scale-up method Introduces a network scale-up method which is a promising method to estimate the size of hard-to-reach populations at both the local and national levels and does not require direct contact with members of hard-to-reach populations, and is much more feasible than many others Features details on how to design, implement, analyze, triangulate results, and extrapolate findings to subnational and national levels using real-world examples of network scale-up projects Is full of real-world examples with appendices that include analysis code in R, Stata, and Excel
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