Erschienen: 06.01.2020 Abbildung von Oliveira / Tuchin | The Optical Clearing Method | 1st ed. 2019 | 2019 | A New Tool for Clinical Practi...

Oliveira / Tuchin

The Optical Clearing Method

A New Tool for Clinical Practice and Biomedical Engineering

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

auch verfügbar als eBook (PDF) für 53.49 €

1st ed. 2019 2019. Buch. xi, 177 S. 6 s/w-Abbildungen, 47 Farbabbildungen, 20 Farbtabellen, Bibliographien. Softcover

Springer. ISBN 978-3-030-33054-5

Format (B x L): 15,5 x 23,5 cm

Gewicht: 302 g

In englischer Sprache

Das Werk ist Teil der Reihe: SpringerBriefs in Physics


This book describes the Optical Immersion Clearing method and its application to acquire information with importance for clinical practice and various fields of biomedical engineering. The method has proved to be a reliable means of increasing tissue transparency, allowing the investigator or surgeon to reach deeper tissue layers for improved imaging and laser surgery. This result is obtained by partial replacement of tissue water with an active optical clearing agent (OCA) that has a higher refractive index and is a better match for the refractive index of other tissue components. Natural tissue scattering is thereby reduced. An exponential increase in research using this method has occurred in recent years, and new applications have emerged, both in clinical practice and in some areas of biomedical engineering. Recent research has revealed that treating ex vivo tissues with solutions containing active OCAs in different concentrations produces experimental data to characterize drug delivery or to discriminate between normal and pathological tissues. The obtained drug diffusion properties are of interest for the pharmaceutical and organ preservation industry. Similar data can be estimated with particular interest for food preservation. The free water content evaluation is also of great interest since it facilitates the characterization of tissues to discriminate pathologies. An interesting new application that is presented in the book regards the creation of two optical windows in the ultraviolet spectral range through the application of the immersion method. These induced transparency windows open the possibility to diagnose and treat pathologies with ultraviolet light. This book presents photographs from the tissues we have studied and figures that represent the experimental setups used. Graphs and tables are also included to show the numerical results obtained in the sequential calculations performed.


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