Mitochondrial Biology and Experimental Therapeutics

1st ed. 2018. Buch. ix, 708 S.: 21 s/w-Abbildungen, 106 Farbabbildungen, 40 Farbtabellen, Bibliographien. Hardcover
Springer ISBN 978-3-319-73343-2
Format (B x L): 15,5 x 23,5 cm
Gewicht: 1227 g
In englischer Sprache
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
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Combines basic research with commercial applications so that the reader can understand the complete process of developing molecules that target mitochondriaIllustrates the role of mitochondria in cell life and cell death in relation to a variety of diseases through the use of illustrative comics in Chapter Discusses the most current issues and advances in the research of mitochondrial-targeted agents and drug therapy
Herausgegeben von: link iconPaulo J. Oliveira