Erschienen: 30.11.1999 Abbildung von Masters / Palsson | Cancer Cell Lines Part 2 | 2002 | 1999

Masters / Palsson

Cancer Cell Lines Part 2

Cancer Cell Lines Part 2

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

ca. 235,39 €

inkl. Mwst.

2002 1999. Buch. x, 377 S. Bibliographien. Hardcover

Springer. ISBN 978-0-7923-5878-7

Format (B x L): 15,6 x 23,4 cm

Gewicht: 1610 g

In englischer Sprache

Das Werk ist Teil der Reihe: Human Cell Culture; 2

Produktbeschreibung

Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading.

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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