Erschienen: 26.01.2010 Abbildung von Lu / Li | Enzyme Inhibition in Drug Discovery and Development | 1. Auflage | 2010

Lu / Li

Enzyme Inhibition in Drug Discovery and Development

The Good and the Bad

lieferbar, ca. 4 Wochen

ca. 209,00 €

inkl. Mwst.

1. Auflage 2010. Buch. 868 S. Hardcover

Wiley. ISBN 978-0-470-28174-1

Format (B x L): 16,5 x 24 cm

Gewicht: 1274 g

In englischer Sprache

Produktbeschreibung

The science and applied approaches of enzyme inhibition in drug discovery and development

Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.

With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions--desirable pharmacological effects--and "bad" inhibitions--drug-drug interactions and toxicity. The book discusses:
* The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment
* The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions
* The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway

Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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