Erschienen: 22.01.2002 Abbildung von Krause | Contrast Agents I | 2002 | Magnetic Resonance Imaging | 221


Contrast Agents I

Magnetic Resonance Imaging

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2002. Buch. x, 249 S. 19 s/w-Abbildungen, 2 Farbabbildungen, 15 s/w-Tabelle, Bibliographien. Hardcover

Springer. ISBN 978-3-540-42247-1

Format (B x L): 15,5 x 23,5 cm

Gewicht: 609 g

In englischer Sprache

Das Werk ist Teil der Reihe: Topics in Current Chemistry; 221


Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].


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