Erschienen: 18.08.2017 Abbildung von Iguchi-Ariga / Ariga | DJ-1/PARK7 Protein | 1. Auflage | 2017 |

Iguchi-Ariga / Ariga

DJ-1/PARK7 Protein

Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases

Buch. Hardcover



In englischer Sprache

Springer-Verlag GmbH. ISBN 9789811065828

Format (B x L): 15.9 x 24.4 cm

Gewicht: 477 g


This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The?DJ-1?gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The?DJ-1?gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of?DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of?DJ-1?in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.?

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