Erschienen: 13.08.2004 Abbildung von Gibbins / Mahaut-Smith | Platelets and Megakaryocytes | 2004 | Volume 2: Perspectives and Tec... | 273

Gibbins / Mahaut-Smith

Platelets and Megakaryocytes

Volume 2: Perspectives and Techniques

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

ca. 235,39 €

inkl. Mwst.

2004. Buch. xx, 504 S. 108 s/w-Abbildungen, 5 Farbabbildungen, Bibliographien. Hardcover

Humana. ISBN 978-1-58829-011-3

Format (B x L): 15,2 x 22,9 cm

Gewicht: 1050 g

In englischer Sprache

Das Werk ist Teil der Reihe: Methods in Molecular Biology; 273

Produktbeschreibung

12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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