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Mechanisms of Angiogenesis

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Springer-Verlag GmbH. ISBN 978-3-7643-7311-5

In englischer Sprache

Das Werk ist Teil der Reihe: Experientia Supplementum

Produktbeschreibung

The induction of blood vessel growth as part of an adaptive process can be either exaggerated, such as in tumors, or too slow, as in ischemic diseases of heart and brain. Therefore it is an interesting target for medical intervention. This volume presents a thorough reconsideration of our current knowledge of factors and principles involved in angiogenic processes. It proceeds from a "macroscopic " perspective through cellular and physical mechanisms to the molecular level . In the first part, angiogenesis in physiological as well as pathological processes is described with a focus on embryogenesis, the reproductive system and the growing heart. The second part deals with cellular and physical mechanisms leading to angiogenesis, and the last part presents a deeper insight into molecular mechanisms of blood vessel growth, including knockout studies of essential angiogenic molecules, the identification of signaling steps in angiogenesis and the importance of cellular junctions. TOC:Angiogenesis during embryonic development.- How do endothelial cells orientate?.- Vascular remodelling by intussusceptive angiogenesis.- Angiogenesis in the reproductive system.- Physiological arteriogenesis in the heart.- Angiogenesis in diseases.- New insights into VEGF-induced angiogenesis.- Can tumor angiogenesis be inhibited without development of "drug"- resistance.- Concerning the role of vessel stability in angiogenesis.- Angiogenesis - a self-regulatory principle in hypoxia.- Sprouting angiogenesis: Why may endothelial cells leave the sheltering vessel?.- Sprouting angiogenesis versus cooption in tumour angiogenesis.- Blood flow and compensatory arteriogenesis.- Role of monocytes in angiogenesis.- Can angiogenesis be exercised?.- Vasculogenesis by bone marrow-derived endothelial progenitor cells.- Signal transduction in angiogenesis.- Role of coagulation in angiogenesis.- Cellular junctions: is there a life without?

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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