Detailsuche

Duffy

Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation
2012. Buch. xxii, 130 S.: Bibliographien. Hardcover
Springer ISBN 978-3-642-24631-9
Format (B x L): 15,5 x 23,5 cm
Gewicht: 397 g
In englischer Sprache
Das Werk ist Teil der Reihe:
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.
Versandkostenfrei
lieferbar (3-5 Tage)
117,69 €
inkl. MwSt.
Webcode: beck-shop.de/ukxxl
Nominated by University College Dublin as an outstanding PhD thesis Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4 Description of an excellent route to a thiophene-containing LXA4 analogue