Erschienen: 05.01.2012 Abbildung von Duffy | Heteroaromatic Lipoxin A4 Analogues | 2012 | Synthesis and Biological Evalu...

Duffy

Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

2012. Buch. xxii, 130 S. Bibliographien. Hardcover

Springer. ISBN 978-3-642-24631-9

Format (B x L): 15,5 x 23,5 cm

Gewicht: 397 g

In englischer Sprache

Das Werk ist Teil der Reihe: Springer Theses

Produktbeschreibung

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

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