Erschienen: 09.07.2015 Abbildung von Doran | Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a-Aryl Ketones | 2015 | 2015 | The Development of a Catalytic...

Doran

Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a-Aryl Ketones

The Development of a Catalytic Asymmetric Synthesis of Tertiary a-Aryl Ketones

2015 2015. Buch. xxi, 202 S. 255 s/w-Abbildungen, 3 Farbabbildungen, Bibliographien. Hardcover

Springer. ISBN 978-3-319-20543-4

Format (B x L): 15,5 x 23,5 cm

Gewicht: 502 g

In englischer Sprache

Das Werk ist Teil der Reihe: Springer Theses

Produktbeschreibung

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.

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