Erschienen: 13.12.2018 Abbildung von Djouder | Prefoldins: the new chaperones | 1. Auflage | 2018 | 1106 |


Prefoldins: the new chaperones

Buch. Hardcover

1st ed. 2018. 2018

ix, 135 S. 3 s/w-Abbildungen, 36 Farbabbildungen, 37 Farbtabellen, Bibliographien

In englischer Sprache

Springer. ISBN 978-3-030-00736-2

Format (B x L): 17,8 x 25,4 cm

Gewicht: 629 g


This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.

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