Erschienen: 03.11.2015 Abbildung von Delcour | Electrophysiology of Unconventional Channels and Pores | 1. Auflage | 2015 | 18 |


Electrophysiology of Unconventional Channels and Pores


Buch. Hardcover

1st ed. 2015. 2015

xi, 385 S. 4 s/w-Tabelle, Bibliographien.

In englischer Sprache

ISBN 978-3-319-20148-1

Format (B x L): 15,5 x 23,5 cm

Gewicht: 7939 g

Das Werk ist Teil der Reihe: Springer Series in Biophysics; 18


This book examines the channels and pores that belong to an eclectic and ubiquitous class of unconventional - and arguably, sometimes strange - pore-forming molecules, which fulfill fundamental roles in various organisms. These non-canonical channels may take on various and sometimes complex architectures, such as large beta-barrels or lipid-containing pores, and may originate from bacteria, viruses or intracellular organelles. For some of them, the physiologically relevant substrate may indeed be ions; for others, it consists of folded polypeptides. Some are released by cells in a soluble form that can pass through biological membranes to exert its permeabilizing effect. Many of these unconventional pores have been investigated by electrophysiology, which, by virtue of its focus on a few or even a single unit, has provided invaluable insights into the mechanisms and structure-function relationships of these remarkable membrane entities. The respective chapters of this book highlight a representative set of these interesting investigations.

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