Erschienen: 10.05.2007 Abbildung von T Cell Activation by CD1 and Lipid Antigens | 2007 | 2007
eBook

T Cell Activation by CD1 and Lipid Antigens

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2007 2007. eBook , eBook. PDF

Springer-Verlag GmbH. ISBN 978-3-540-69511-0

In englischer Sprache

Produktbeschreibung

There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease. TOC:Section 1 - Molecular Biology.- Chapter 1 - Evolutionary Biology of the CD1.- Chapter 2 - Architecture of CD1 Proteins.- Chapter 3 - Structures and Biology of Self Lipid Antigens.- Chapter 4 - Structures and Functions of Microbial Lipid Antigens.- Section 2 - Cellular Biology.- Chapter 5 - CD1 Expression on Antigen Presenting Cells.- Chapter 6 - Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading and Presentation.- Chapter 7 - TCR-Mediated Recognition of Glycolipid CD1 Complexes.- Chapter 8 - Development and Selection of Va14i NKT Cells.- Section 3 - Disease.- Chapter 9 - CD1-Restricted T Cells in Host Defense to Infectious Diseases.- Chapter 10 - NKT Cells and Autoimmune Diseases: Unraveling the Complexity.- Chapter 11 - iNKT Cells in Allergic Disease.- Chapter 12 - CD1-Restricted T Cells and Tumor Immunity.- Chapter 13 - Harnessing NKT Cells for Therapeutic Applications.- Subject index.

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