Erschienen: 04.02.2006 Abbildung von Dislocation and Degradation of Proteins from the Endoplasmic Reticulum | 2005 | 2006
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Dislocation and Degradation of Proteins from the Endoplasmic Reticulum

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2005 2006. eBook , eBook. PDF

Springer-Verlag GmbH. ISBN 978-3-540-28007-1

In englischer Sprache

Produktbeschreibung

The present volume of Current Topics in Microbiology and Immunology contains seven chapters that illuminate various aspects of a protein's genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance since the malfunctioning of proper quality control during protein synthesis, and the lack of sufficient degradation of improper proteins from the ER forms the basis of many human diseases. The study of viruses and bacteria has significantly contributed to the understanding of the processes going on at the ER membrane, which is illustrated in several chapters of the volume. The field of protein degradation from the ER touches upon many other fields of cell biology, such as immunology, pathology, microbiology, and embryology. TOC:Preface.- The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum associated degradation.- Recognition and delivery of ERAD substrates to the proteasome, and alternative paths for cell survival.- CPY and the power of yeast genetics in the elucidation of quality control and associated protein degradation of the endoplasmic reticulum.- The role of the ubiquitination machinery in dislocation and degradation of endoplasmic reticulum proteins.- The role of p97/Cdc48p in ERAD: From the immune system to yeast.- The ins and outs of intracellular peptides and antigen presentation by MHC class I molecules.- Entry of protein toxins into mammalian cells by crossing the ER membrane: co-opting basic mechanisms of ERAD.- Subject index.

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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