Erschienen: 27.03.2019 Abbildung von Chakraborti / Dhalla | Regulation of Membrane Na+-K+ ATPase | 1. Auflage | 2019 | 15 | beck-shop.de

Chakraborti / Dhalla

Regulation of Membrane Na+-K+ ATPase

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

Buch. Softcover

Softcover reprint of the original 1st ed. 2016. 2019

xi, 436 S. 56 s/w-Abbildungen, 44 Farbabbildungen, 16 s/w-Tabelle, Bibliographien

In englischer Sprache

Springer. ISBN 978-3-319-79672-7

Format (B x L): 15,5 x 23,5 cm

Gewicht: 682 g

Produktbeschreibung

Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s a- and ß- subunits. At present four different a- (a-1,a-2,a-3 and a-4) and three ß- (ß-1, ß-2, and ß-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of a- and ß- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembrane domain adjacent to the isoform(s) of a-ß subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.

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