Erschienen: 31.05.1990 Abbildung von Alvarez-Leefmans / Russell | Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells | 1990

Alvarez-Leefmans / Russell

Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

lieferbar ca. 10 Tage als Sonderdruck ohne Rückgaberecht

ca. 219,99 €

inkl. Mwst.

1990. Buch. xviii, 426 S. Bibliographien. Hardcover

Springer. ISBN 978-0-306-43426-6

Format (B x L): 17,8 x 25,4 cm

Gewicht: 2350 g

In englischer Sprache

Produktbeschreibung

This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther­ modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem­ brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener­ alized and virtually all cells were thought to have a very high P Cl and a ther­ modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

Gesamtwerk

Die 8. Auflage ist wieder auf sechs Bände angelegt. Darin finden sich übersichtlich und in systematischer Gliederung Vertragsmuster aus der Feder erfahrener Experten. Jedem dieser Muster folgen Anmerkungen, mit denen der dem Vertragsentwurf zu Grunde liegende Sachverhalt und die Gründe für die Wahl des spezifischen Formulars erläutert werden.

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